Post Exposure Effects of Propoxur (Agricultural Pesticide) on Male Fertility in Wistar Rat

نویسندگان

  • Arthénice Jemima Guiekep Nounamo Department of Animal Production, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon.
  • Augustave Kenfack Department of Animal Production, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon.
  • Edouard Akono Nantia Department of Biochemistry, Faculty of Science, University of Bamenda, Bambili, Cameroon.
  • Ferdinand Ngoula Department of Animal Production, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon.
  • Joseph Tchoumboue Department of Animal Production, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon.
  • Pierre Kamtchouing Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
چکیده مقاله:

Background: Pesticide toxicity is one of the major environmental health problems for the modern societies, as some of the effects may last long time after exposure. Propoxur is one of the Carbamate pesticide largely used in agriculture in the Western region of Cameroon. Methods: In order to evaluate the post-exposure effects of propoxur, 48 male rats (12 animals per group) aged 30 d were orally gavaged with 0.00, 1.73, 2.60 and 5.20 mg.kg-1 body weight of propoxur for 90 d. At the end of treatment, 6 rats per group were sacrificed and others were followed up for 90 additional days and submitted to a fertility test before sacrifice. Results: At the end of exposure propoxur significantly increased (P<0.05) the testis weight while it decreased (P<0.05) the cauda epididymal sperm motility in rat. Propoxur treatment and post-treatment exposure showed variable effect on the fertility rate with an increase and decrease at 2.60 and 5.20 mg.kg-1, respectively. At the 90th day post treatment, there was a significant decrease (P<0.05) in epididymis weight and sperm count and motility (P<0.05). In addition, post-exposure treatment with propoxur reduced (P<0.05) the pup litter size and the sex ratio at all doses. Histopathological examination revealed a high vacuity of germinal epithelia in treated rats that persisted after post-exposure time. Conclusion: Propoxur negatively affected male rats&rsquo; reproductive parameters with more significant adverse effects observed 90 d after the end of exposure.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pesticide Exposure and Depression among Male Private Pesticide Applicators in the Agricultural Health Study

BACKGROUND Pesticide exposure may be positively associated with depression. Few previous studies have considered the episodic nature of depression or examined individual pesticides. OBJECTIVE We evaluated associations between pesticide exposure and depression among male private pesticide applicators in the Agricultural Health Study. METHODS We analyzed data for 10 pesticide classes and 50 s...

متن کامل

The Biological Effects of Imatinib on Male Fertility of Wistar Rats

Background Imatinib is used in chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. The major aim of this study was to investigate the effects of Imatinib on male fertility in Wistar rats. MaterialsAndMethods Three groups of rats were gavaged with 6, 9, and 12 mg/kg Imatinib dissolved in dH2O for 30 consecutive days. On days 7, 14 and 3...

متن کامل

Developmental Exposure to Low-Dose PBDE-99: Effects on Male Fertility and Neurobehavior in Rat Offspring

In utero exposure to a single low dose of 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) disrupts neurobehavioral development and causes permanent effects on the rat male reproductive system apparent in adulthood. PBDEs, a class of flame retardants, are widely used in every sector of modern life to prevent fire. They are persistent in the environment, and increasing levels of PBDEs have been fo...

متن کامل

P-79: The Study of Levofloxacin Antibiotic Effects on Male Sexual Hormone in Wistar Rat

Background: Levofloxacinis a fluoroquinolone antibacterial agent with a broad spectrum of activity against different infectious disease and Gram-negative bacteria. In more than 100 countries it has therapeutic use. This study is aimed to determine Cytotoxic of Levofloxacin effects on rat testis tissue. Materials and Methods: For this experimental study, we used 50 male wistar rats which must be...

متن کامل

Effects of propoxur on the reproductive system of male rats.

The reproductive toxicity of propoxur (2-isopropoxy-phenyl-N-methylcarbamate), a carbamate pesticide, was investigated in adult male Wistar rats exposed to 0, 1.73, 2.6, and 5.2 mg/kg body weight/day for 90 successive days. Results obtained from this study showed a significant (p < 0.05) concentration-dependent increase in food consumption, relative weights of testis, epididymis and kidneys wit...

متن کامل

Effects of radio waves on male fertility

In recent years, male fertility has changed due to the effects of environmental, health and lifestyle factors and the infertility rate has increased, to the extent that male fertility may be affected by extreme heat, exposure to pesticides, radiation, substances Changes in radioactivity, lifestyle, stress and occupation. In the environment, there are ionizing and non-ionizing rays whose effect...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 12  شماره None

صفحات  21- 27

تاریخ انتشار 2018-04

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023